EVALUATION OF TRIPLE AND QUADRUPLE REGIMENS IN ERADICATION OF HELICOBACTER PYLORI INFECTION IN PEDIATRIC PATIENTS IN EMAM KHOMEINI HOSPITAL IN 2002-2003: A RANDOMIZED CLINICAL TRIAL

Authors

  • A. ZAMANI Pediatric Infectious Disease Department, Emam Khomeini Hospital, TehranUniversity of Medical Sciences.
  • FAROUKH TIRGARI Pathology Department, EmamKhomeini Hospital, Tehran University of Medical Sciences.
  • H. FOROUTAN Gastroenterology Branch of the Department of Internal Medicine,Emam Khomeini Hospital, Tehran University of Medical Sciences.
  • HESHMAT MOAYERI Pediatric Endocrinology Department, EmamKhomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
  • LALEH RAZAVI Pediatric Ward, Emam KhomeiniHospital, Tehran University of Medical Sciences.
  • SHAHLA BAHREMAND Pediatric Gastroenterology Department, Emam Khomeini Hospital, Tehran University ofMedical Sciences.
  • SHAMSOLLAH NOORIPOUR
Abstract:

 ABSTRACT Background: Triple therapy with a proton pump inhibitor, clarithromycin and amoxicillin and quadruple therapy with a proton pump inhibitor, bismuth citrate, metronidazole and amoxicillin have been proposed in Maastricht 2000 as the optimal treatment of Helicobacter pylori infection. We aimed to compare these two regimens in Iranian pediatric patients. Methods: A randomized clinical trial in Em am Khomeini Hospital between 13 81 and 1382 was done. Patients with confirmed H. pylori infection by histology were divided in to two groups in a randomized 1: 1 scheme. Triple regimen group: Clarithromycin 15 mg/kg/d, Amoxicillin 50 mglkg/d and Omeprazole 1 mg/kg/day for 10 days. Quadruple regimen group: Omeprazole 1 mg/kg/d, Amoxicillin 50 mglkg/day, Metronidazole 20 mglkg/day and Bismuth citrate 8 mglkg for 10 days. The eradication was assessed by c-urea breath test 4 weeks after the end of treatment and byperprotocol analysis. Results: In our study, 100 patients (50 in each group) were found and the eradication rates in the triple and quadruple group were 92% and 84% respectively (p=0.046). Conclusion: According to our results, we recommend triple therapy as first-line treatment in Iranian pediatric patients and quadruple therapy as a second line regimen.

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evaluation of triple and quadruple regimens in eradication of helicobacter pylori infection in pediatric patients in emam khomeini hospital in 2002-2003: a randomized clinical trial

abstract background: triple therapy with a proton pump inhibitor, clarithromycin and amoxicillin and quadruple therapy with a proton pump inhibitor, bismuth citrate, metronidazole and amoxicillin have been proposed in maastricht 2000 as the optimal treatment of helicobacter pylori infection. we aimed to compare these two regimens in iranian pediatric patients. methods: a randomized clinical tri...

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EVALUATION OF TRIPLE AND QUADRUPLE REGIMENS IN ERADICATION OF HELICOBACTER PYLORI INFECTION IN PEDIATRIC PATIENTS IN EMAM KHOMEINI HOSPITAL IN 2002-2003: A RANDONUZEDCL�CAL TRlAL

Background: Triple therapy with a proton pump inhibitor, c1arithromycin and amoxicillin and quadruple therapy with a proton pump inhibitor, bismuth citrate, met­ ronidazole and amoxicillin have been proposed in Maastricht 2000 as the optimal treat­ ment of Helicobacter pylori infection. We aimed to compare these two regimens in Iranian pediatric patients. Methods: A randomized clinical trial in...

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Journal title

volume 19  issue 1

pages  29- 33

publication date 2005-05

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